Acute loss of TET function results in aggressive myeloid cancer in mice

TET-family dioxygenases oxidize 5-methylcytosine (5mC) in DNA, and exert tumour suppressor activity in many types of cancers. Even in the absence of TET coding region mutations, TET loss-of-function is strongly associated with cancer. Here we show that acute elimination of TET function induces the r...

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Detalles Bibliográficos
Autores principales: An, Jungeun, González-Avalos, Edahí, Chawla, Ashu, Jeong, Mira, López-Moyado, Isaac F., Li, Wei, Goodell, Margaret A., Chavez, Lukas, Ko, Myunggon, Rao, Anjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674670/
https://www.ncbi.nlm.nih.gov/pubmed/26607761
http://dx.doi.org/10.1038/ncomms10071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674670/
https://www.ncbi.nlm.nih.gov/pubmed/26607761
http://dx.doi.org/10.1038/ncomms10071

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