An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1

PAK4 is a metazoan-specific kinase acting downstream of Cdc42. Here we describe the structure of human PAK4 in complex with Inka1, a potent endogenous kinase inhibitor. Using single mammalian cells containing crystals 50 μm in length, we have determined the in cellulo crystal structure at 2.95 Å res...

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Detalles Bibliográficos
Autores principales: Baskaran, Yohendran, Ang, Khay C., Anekal, Praju V., Chan, Wee L., Grimes, Jonathan M., Manser, Ed, Robinson, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674680/
https://www.ncbi.nlm.nih.gov/pubmed/26607847
http://dx.doi.org/10.1038/ncomms9681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674680/
https://www.ncbi.nlm.nih.gov/pubmed/26607847
http://dx.doi.org/10.1038/ncomms9681

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