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Alternative splicing of Drosophila Nmnat functions as a switch to enhance neuroprotection under stress

Nicotinamide mononucleotide adenylyltransferase (NMNAT) is a conserved enzyme in the NAD synthetic pathway. It has also been identified as an effective and versatile neuroprotective factor. However, it remains unclear how healthy neurons regulate the dual functions of NMNAT and achieve self-protecti...

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Detalles Bibliográficos
Autores principales: Ruan, Kai, Zhu, Yi, Li, Chong, Brazill, Jennifer M., Zhai, R. Grace
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674693/
https://www.ncbi.nlm.nih.gov/pubmed/26616331
http://dx.doi.org/10.1038/ncomms10057