PTEN stabilizes TOP2A and regulates the DNA decatenation

PTEN is a powerful tumor suppressor that antagonizes the cytoplasmic PI3K-AKT pathway and suppresses cellular proliferation. PTEN also plays a role in the maintenance of genomic stability in the nucleus. Here we report that PTEN facilitates DNA decatenation and controls a decatenation checkpoint. Ca...

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Detalles Bibliográficos
Autores principales: Kang, Xi, Song, Chang, Du, Xiao, Zhang, Cong, Liu, Yu, Liang, Ling, He, Jinxue, Lamb, Kristy, Shen, Wen H., Yin, Yuxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674714/
https://www.ncbi.nlm.nih.gov/pubmed/26657567
http://dx.doi.org/10.1038/srep17873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674714/
https://www.ncbi.nlm.nih.gov/pubmed/26657567
http://dx.doi.org/10.1038/srep17873

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