Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons

The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that regulates cell cycle progression in proliferating cells. To enter the S-phase, APC/C must be inactivated by phosphorylation of its cofactor, Cdh1. In post-mitotic cells such as neurons APC/C-Cdh1 complex is highly active...

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Detalles Bibliográficos
Autores principales: Veas-Pérez de Tudela, Miguel, Maestre, Carolina, Delgado-Esteban, María, Bolaños, Juan P., Almeida, Angeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674757/
https://www.ncbi.nlm.nih.gov/pubmed/26658992
http://dx.doi.org/10.1038/srep18180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674757/
https://www.ncbi.nlm.nih.gov/pubmed/26658992
http://dx.doi.org/10.1038/srep18180

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