Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease

Alzheimer's disease (AD) is characterized by synapse loss due to mechanisms that remain poorly understood. We show that the neural cell adhesion molecule 2 (NCAM2) is enriched in synapses in the human hippocampus. This enrichment is abolished in the hippocampus of AD patients and in brains of m...

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Detalles Bibliográficos
Autores principales: Leshchyns'ka, Iryna, Liew, Heng Tai, Shepherd, Claire, Halliday, Glenda M., Stevens, Claire H., Ke, Yazi D., Ittner, Lars M., Sytnyk, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674770/
https://www.ncbi.nlm.nih.gov/pubmed/26611261
http://dx.doi.org/10.1038/ncomms9836

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674770/
https://www.ncbi.nlm.nih.gov/pubmed/26611261
http://dx.doi.org/10.1038/ncomms9836

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