DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice

Maintaining DNA integrity is vital for all cells and organisms. Defective DNA repair may contribute to neurological disorders, including Alzheimer's disease (AD). We found reduced levels of BRCA1, but not of other DNA repair factors, in the brains of AD patients and human amyloid precursor prot...

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Detalles Bibliográficos
Autores principales: Suberbielle, Elsa, Djukic, Biljana, Evans, Mark, Kim, Daniel H., Taneja, Praveen, Wang, Xin, Finucane, Mariel, Knox, Joseph, Ho, Kaitlyn, Devidze, Nino, Masliah, Eliezer, Mucke, Lennart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674776/
https://www.ncbi.nlm.nih.gov/pubmed/26615780
http://dx.doi.org/10.1038/ncomms9897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674776/
https://www.ncbi.nlm.nih.gov/pubmed/26615780
http://dx.doi.org/10.1038/ncomms9897

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