Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance

The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonly overexpressed in cancers and is implicated in the development of chemoresistance. The use of drugs inhibiting MGMT has been hindered by their haematologic toxicity and inefficiency. As a different strategy to inhibit MGM...

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Detalles Bibliográficos
Autores principales: Wickström, Malin, Dyberg, Cecilia, Milosevic, Jelena, Einvik, Christer, Calero, Raul, Sveinbjörnsson, Baldur, Sandén, Emma, Darabi, Anna, Siesjö, Peter, Kool, Marcel, Kogner, Per, Baryawno, Ninib, Johnsen, John Inge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674781/
https://www.ncbi.nlm.nih.gov/pubmed/26603103
http://dx.doi.org/10.1038/ncomms9904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674781/
https://www.ncbi.nlm.nih.gov/pubmed/26603103
http://dx.doi.org/10.1038/ncomms9904

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