miRNA–target chimeras reveal miRNA 3′-end pairing as a major determinant of Argonaute target specificity

microRNAs (miRNAs) act as sequence-specific guides for Argonaute (AGO) proteins, which mediate posttranscriptional silencing of target messenger RNAs. Despite their importance in many biological processes, rules governing AGO–miRNA targeting are only partially understood. Here we report a modified A...

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Detalles Bibliográficos
Autores principales: Moore, Michael J., Scheel, Troels K. H., Luna, Joseph M., Park, Christopher Y., Fak, John J., Nishiuchi, Eiko, Rice, Charles M., Darnell, Robert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674787/
https://www.ncbi.nlm.nih.gov/pubmed/26602609
http://dx.doi.org/10.1038/ncomms9864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674787/
https://www.ncbi.nlm.nih.gov/pubmed/26602609
http://dx.doi.org/10.1038/ncomms9864

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