Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells

Mechanical ventilation (MV) of patients can cause damage to bronchoalveolar epithelium, leading to a sterile inflammatory response, infection and in severe cases sepsis. Limited knowledge is available on the effects of MV on the innate immune defense system in the human lung. In this study, we demon...

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Detalles Bibliográficos
Autores principales: Karadottir, Harpa, Kulkarni, Nikhil Nitin, Gudjonsson, Thorarinn, Karason, Sigurbergur, Gudmundsson, Gudmundur Hrafn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2015
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675098/
https://www.ncbi.nlm.nih.gov/pubmed/26664810
http://dx.doi.org/10.7717/peerj.1483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675098/
https://www.ncbi.nlm.nih.gov/pubmed/26664810
http://dx.doi.org/10.7717/peerj.1483

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