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Protein Kinase C-Independent Inhibition of Organic Cation Transporter 1 Activity by the Bisindolylmaleimide Ro 31-8220

Ro 31–8220 is a potent protein kinase C (PKC) inhibitor belonging to the chemical class of bisindolylmaleimides (BIMs). Various PKC-independent effects of Ro 31–8220 have however been demonstrated, including inhibition of the ATP-binding cassette drug transporter breast cancer resistance protein. In...

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Detalles Bibliográficos
Autores principales: Mayati, Abdullah, Bruyere, Arnaud, Moreau, Amélie, Jouan, Elodie, Denizot, Claire, Parmentier, Yannick, Fardel, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675551/
https://www.ncbi.nlm.nih.gov/pubmed/26657401
http://dx.doi.org/10.1371/journal.pone.0144667