Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors

Cysteine proteases continue to provide validated targets for treatment of human diseases. In neurodegenerative disorders, multiple cysteine proteases provide targets for enzyme inhibitors, notably caspases, calpains, and cathepsins. The reactive, active-site cysteine provides specificity for many in...

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Detalles Bibliográficos
Autores principales: Siklos, Marton, BenAissa, Manel, Thatcher, Gregory R.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675809/
https://www.ncbi.nlm.nih.gov/pubmed/26713267
http://dx.doi.org/10.1016/j.apsb.2015.08.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675809/
https://www.ncbi.nlm.nih.gov/pubmed/26713267
http://dx.doi.org/10.1016/j.apsb.2015.08.001

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