The G-Protein-Coupled Bile Acid Receptor Gpbar1 (TGR5) Inhibits Gastric Inflammation Through Antagonizing NF-κB Signaling Pathway

Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well-known for its roles in regulation of energy homeostasis and glucose metabolism. Here, we show that mice lacking TGR5 were much more susceptible to lipopolysaccharide (LPS)-induced acute gastric inflammation than wild-type (WT) mice and TGR5...

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Detalles Bibliográficos
Autores principales: Guo, Cong, Qi, Hui, Yu, Yingjie, Zhang, Qiqi, Su, Jia, Yu, Donna, Huang, Wendong, Chen, Wei-Dong, Wang, Yan-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675858/
https://www.ncbi.nlm.nih.gov/pubmed/26696888
http://dx.doi.org/10.3389/fphar.2015.00287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675858/
https://www.ncbi.nlm.nih.gov/pubmed/26696888
http://dx.doi.org/10.3389/fphar.2015.00287

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