A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys

Bispecific antibodies, while showing great therapeutic potential, pose formidable challenges with respect to their assembly, stability, immunogenicity, and pharmacodynamics. Here we describe a novel class of bispecific antibodies with native human immunoglobulin format. The design exploits differenc...

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Detalles Bibliográficos
Autores principales: Smith, Eric J., Olson, Kara, Haber, Lauric J., Varghese, Bindu, Duramad, Paurene, Tustian, Andrew D., Oyejide, Adelekan, Kirshner, Jessica R., Canova, Lauren, Menon, Jayanthi, Principio, Jennifer, MacDonald, Douglas, Kantrowitz, Joel, Papadopoulos, Nicholas, Stahl, Neil, Yancopoulos, George D., Thurston, Gavin, Davis, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675964/
https://www.ncbi.nlm.nih.gov/pubmed/26659273
http://dx.doi.org/10.1038/srep17943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675964/
https://www.ncbi.nlm.nih.gov/pubmed/26659273
http://dx.doi.org/10.1038/srep17943

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