Repression of AKT signaling by ARQ 092 in cells and tissues from patients with Proteus syndrome

A somatic activating mutation in AKT1, c.49G>A, pGlu17Lys, that results in elevated AKT signaling in mutation-positive cells, is responsible for the mosaic overgrowth condition, Proteus syndrome. ARQ 092 is an allosteric pan-AKT inhibitor under development for treatment in cancer. We tested the e...

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Detalles Bibliográficos
Autores principales: Lindhurst, Marjorie J., Yourick, Miranda R., Yu, Yi, Savage, Ronald E., Ferrari, Dora, Biesecker, Leslie G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675973/
https://www.ncbi.nlm.nih.gov/pubmed/26657992
http://dx.doi.org/10.1038/srep17162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675973/
https://www.ncbi.nlm.nih.gov/pubmed/26657992
http://dx.doi.org/10.1038/srep17162

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