Expression and Dendritic Trafficking of BDNF-6 Splice Variant are Impaired in Knock-In Mice Carrying Human BDNF Val66Met Polymorphism

BACKGROUND: The human Val66Met polymorphism in brain-derived neurotrophic factor (BDNF), a key factor in neuroplasticity, synaptic function, and cognition, has been implicated in the pathophysiology of neuropsychiatric and neurodegenerative disorders. BDNF is encoded by multiple transcripts with dis...

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Detalles Bibliográficos
Autores principales: Mallei, Alessandra, Baj, Gabriele, Ieraci, Alessandro, Corna, Stefano, Musazzi, Laura, Lee, Francis S., Tongiorgi, Enrico, Popoli, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675980/
https://www.ncbi.nlm.nih.gov/pubmed/26108221
http://dx.doi.org/10.1093/ijnp/pyv069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675980/
https://www.ncbi.nlm.nih.gov/pubmed/26108221
http://dx.doi.org/10.1093/ijnp/pyv069

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