Variant fatty acid-like molecules Conjugation, novel approaches for extending the stability of therapeutic peptides

The multiple physiological properties of glucagon-like peptide-1 (GLP-1) make it a promising drug candidate for the treatment of type 2 diabetes. However, the in vivo half-life of GLP-1 is short due to rapid degradation by dipeptidyl peptidase-IV (DPP-IV) and renal clearance. The poor stability of G...

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Detalles Bibliográficos
Autores principales: Li, Ying, Wang, Yuli, Wei, Qunchao, Zheng, Xuemin, Tang, Lida, Kong, Dexin, Gong, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676015/
https://www.ncbi.nlm.nih.gov/pubmed/26658631
http://dx.doi.org/10.1038/srep18039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676015/
https://www.ncbi.nlm.nih.gov/pubmed/26658631
http://dx.doi.org/10.1038/srep18039

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