Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy

The role of lysosomes in acetaminophen (APAP) hepatotoxicity is poorly understood. Here, we investigated the impact of genetic and drug-induced lysosomal cholesterol (LC) accumulation in APAP hepatotoxicity. Acid sphingomyelinase (ASMase)(−/−) mice exhibit LC accumulation and higher mortality after...

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Detalles Bibliográficos
Autores principales: Baulies, Anna, Ribas, Vicent, Núñez, Susana, Torres, Sandra, Alarcón-Vila, Cristina, Martínez, Laura, Suda, Jo, Ybanez, Maria D., Kaplowitz, Neil, García-Ruiz, Carmen, Fernández-Checa, Jose C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676017/
https://www.ncbi.nlm.nih.gov/pubmed/26657973
http://dx.doi.org/10.1038/srep18017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676017/
https://www.ncbi.nlm.nih.gov/pubmed/26657973
http://dx.doi.org/10.1038/srep18017

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