Cargando…

TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III

BACKGROUND: Transmembrane protein 106B (TMEM106B) has been identified as a risk factor for frontotemporal lobar degeneration, which is the second most common form of progressive dementia in people under 65 years of age. Mutations in charged multivesicular body protein 2B (CHMP2B), which is involved...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jun, Mi-Hee, Han, Jeong-Ho, Lee, Yu-Kyung, Jang, Deok-Jin, Kaang, Bong-Kiun, Lee, Jin-A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676093/ https://www.ncbi.nlm.nih.gov/pubmed/26651479 http://dx.doi.org/10.1186/s13041-015-0177-z

Ejemplares similares

Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown
por: Clayton, Emma L, et al.
Publicado: (2018)

TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration
por: van der Zee, Julie, et al.
Publicado: (2011)

TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort
por: van der Zee, Julie, et al.
Publicado: (2011)

Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain
por: Busch, Johanna I, et al.
Publicado: (2013)

Loss of TMEM106B potentiates lysosomal and FTLD‐like pathology in progranulin‐deficient mice
por: Werner, Georg, et al.
Publicado: (2020)

Lack of a protective effect of the Tmem106b “protective SNP” in the Grn knockout mouse model for frontotemporal lobar degeneration
por: Cabron, Anne-Sophie, et al.
Publicado: (2023)

Frontotemporal Dementia Caused by CHMP2B Mutations
por: Isaacs, A.M, et al.
Publicado: (2011)

TMEM106B, a risk factor for FTLD and aging, has an intrinsically disordered cytoplasmic domain
por: Kang, Jian, et al.
Publicado: (2018)

Delusion of Pregnancy in Frontotemporal Lobar Degeneration with Motor Neurone Disease (FTLD/MND)
por: Larner, A. J.
Publicado: (2008)

Presymptomatic cerebral blood flow changes in CHMP2B mutation carriers of familial frontotemporal dementia (FTD-3), measured with MRI
por: Lunau, Line, et al.
Publicado: (2012)

AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b(−/−)Grn(−/−) mice
por: Feng, Tuancheng, et al.
Publicado: (2023)

A novel temporal‐predominant neuro‐astroglial tauopathy associated with TMEM106B gene polymorphism in FTLD/ALS‐TDP
por: Llibre‐Guerra, Jorge J., et al.
Publicado: (2021)

Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations
por: Urwin, Hazel, et al.
Publicado: (2010)

Cortical Frontoparietal Network Dysfunction in CHMP2B-Frontotemporal Dementia
por: Musaeus, Christian Sandøe, et al.
Publicado: (2021)

The ESCRT-III isoforms CHMP2A and CHMP2B display different effects on membranes upon polymerization
por: Alqabandi, Maryam, et al.
Publicado: (2021)

Case report: TMEM106B haplotype alters penetrance of GRN mutation in frontotemporal dementia family
por: Perneel, Jolien, et al.
Publicado: (2023)

Measurement and characterization of distinctive clinical phenotypes using the Frontotemporal Lobar Degeneration Module (FTLD-MOD)
por: Gefen, Tamar, et al.
Publicado: (2020)

Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation
por: Bauer, Claudia S., et al.
Publicado: (2022)

The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei
por: Coyne, Alyssa N., et al.
Publicado: (2021)

Retrovirus reactivation in CHMP2B(Intron5) models of frontotemporal dementia
por: Fort-Aznar, Laura, et al.
Publicado: (2020)

A 3’UTR Insertion Is a Candidate Causal Variant at the TMEM106B Locus Associated with Increased Risk for FTLD-TDP
por: Chemparathy, Augustine, et al.
Publicado: (2023)

Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B
por: Yang, Dong, et al.
Publicado: (2008)

The major TMEM106B dementia risk allele affects TMEM106B protein levels and myelin lipid homeostasis in the ageing human hippocampus
por: Lee, Jun Yup, et al.
Publicado: (2023)

The TMEM106B risk allele is associated with lower cortical volumes in a clinically diagnosed frontotemporal dementia cohort
por: Harding, Sophie R, et al.
Publicado: (2017)

Cognitive reserve and TMEM106B genotype modulate brain damage in presymptomatic frontotemporal dementia: a GENFI study
por: Premi, Enrico, et al.
Publicado: (2017)

Identification of TMEM106B amyloid fibrils provides an updated view of TMEM106B biology in health and disease
por: Perneel, Jolien, et al.
Publicado: (2022)

C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes
por: T. Vicente, Cristina, et al.
Publicado: (2023)

Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology
por: Clayton, Emma L., et al.
Publicado: (2015)

Neuroprotective activity of ursodeoxycholic acid in CHMP2B(Intron5) models of frontotemporal dementia
por: West, Ryan J.H., et al.
Publicado: (2020)

Editorial: The role of gene mutations in the neuropathology of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD)– Progress and challenges
por: Troakes, Claire, et al.
Publicado: (2023)

The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus
por: Lee, Jun Yup, et al.
Publicado: (2023)

Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1
por: Cada, A. King, et al.
Publicado: (2022)

Variation in TMEM106B in chronic traumatic encephalopathy
por: Cherry, Jonathan D., et al.
Publicado: (2018)

Midbody Remnant Inheritance Is Regulated by the ESCRT Subunit CHMP4C
por: Casares-Arias, Javier, et al.
Publicado: (2020)

Antibody-recognizing residues 188-211 of TMEM106B exhibit immunohistochemical reactivity with the TMEM106B C-terminal fragment
por: Ishikawa, Ruoyi, et al.
Publicado: (2023)

Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B
por: Zhang, Yu, et al.
Publicado: (2017)

Synaptopathy in CHMP2B frontotemporal dementia highlights the synaptic vesicle cycle as a therapeutic target
por: Robbins, Miranda, et al.
Publicado: (2022)

TMEM106B aggregation in neurodegenerative diseases: linking genetics to function
por: Jiao, Hai-Shan, et al.
Publicado: (2023)

Lysosomal dysfunction in TMEM106B hypomyelinating leukodystrophy
por: Ito, Yoko, et al.
Publicado: (2018)

The ESCRT protein Chmp4c regulates mitotic spindle checkpoint signaling
por: Petsalaki, Eleni, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_tjnsb57djlpbe5f1alh04vp1bp