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Parameterizing sequence alignment with an explicit evolutionary model
BACKGROUND: Inference of sequence homology is inherently an evolutionary question, dependent upon evolutionary divergence. However, the insertion and deletion penalties in the most widely used methods for inferring homology by sequence alignment, including BLAST and profile hidden Markov models (pro...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676179/ https://www.ncbi.nlm.nih.gov/pubmed/26652060 http://dx.doi.org/10.1186/s12859-015-0832-5 |