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Defining the Role of Tyrosine and Rational Tuning of Oxidase Activity by Genetic Incorporation of Unnatural Tyrosine Analogs
[Image: see text] While a conserved tyrosine (Tyr) is found in oxidases, the roles of phenol ring pK(a) and reduction potential in O(2) reduction have not been defined despite many years of research on numerous oxidases and their models. These issues represent major challenges in our understanding o...
Autores principales: | Yu, Yang, Lv, Xiaoxuan, Li, Jiasong, Zhou, Qing, Cui, Chang, Hosseinzadeh, Parisa, Mukherjee, Arnab, Nilges, Mark J., Wang, Jiangyun, Lu, Yi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2015
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676419/ https://www.ncbi.nlm.nih.gov/pubmed/25672571 http://dx.doi.org/10.1021/ja5109936 |
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