A Basis for Rapid Clearance of Circulating Ring-Stage Malaria Parasites by the Spiroindolone KAE609

Recent clinical trials revealed a surprisingly rapid clearance of red blood cells (RBCs) infected with malaria parasites by the spiroindolone KAE609. Here, we show that ring-stage parasite–infected RBCs exposed to KAE609 become spherical and rigid, probably through osmotic dysregulation consequent t...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Rou, Suwanarusk, Rossarin, Malleret, Benoit, Cooke, Brian M., Nosten, Francois, Lau, Yee-Ling, Dao, Ming, Lim, Chwee Teck, Renia, Laurent, Tan, Kevin Shyong Wei, Russell, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676544/
https://www.ncbi.nlm.nih.gov/pubmed/26136472
http://dx.doi.org/10.1093/infdis/jiv358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676544/
https://www.ncbi.nlm.nih.gov/pubmed/26136472
http://dx.doi.org/10.1093/infdis/jiv358

Ejemplares similares