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A Basis for Rapid Clearance of Circulating Ring-Stage Malaria Parasites by the Spiroindolone KAE609

Recent clinical trials revealed a surprisingly rapid clearance of red blood cells (RBCs) infected with malaria parasites by the spiroindolone KAE609. Here, we show that ring-stage parasite–infected RBCs exposed to KAE609 become spherical and rigid, probably through osmotic dysregulation consequent t...

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Detalles Bibliográficos
Autores principales:	Zhang, Rou, Suwanarusk, Rossarin, Malleret, Benoit, Cooke, Brian M., Nosten, Francois, Lau, Yee-Ling, Dao, Ming, Lim, Chwee Teck, Renia, Laurent, Tan, Kevin Shyong Wei, Russell, Bruce
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Major Articles and Brief Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676544/ https://www.ncbi.nlm.nih.gov/pubmed/26136472 http://dx.doi.org/10.1093/infdis/jiv358

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