Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia

Necroptosis is a highly pro-inflammatory mode of cell death regulated by RIP (or RIPK)1 and RIP3 kinases and mediated by the effector MLKL. We report that diverse bacterial pathogens that produce a pore-forming toxin (PFT) induce necroptosis of macrophages and this can be blocked for protection agai...

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Detalles Bibliográficos
Autores principales: González-Juarbe, Norberto, Gilley, Ryan Paul, Hinojosa, Cecilia Anahí, Bradley, Kelley Margaret, Kamei, Akinobu, Gao, Geli, Dube, Peter Herman, Bergman, Molly Ann, Orihuela, Carlos Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676650/
https://www.ncbi.nlm.nih.gov/pubmed/26659062
http://dx.doi.org/10.1371/journal.ppat.1005337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676650/
https://www.ncbi.nlm.nih.gov/pubmed/26659062
http://dx.doi.org/10.1371/journal.ppat.1005337

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