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Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia

Necroptosis is a highly pro-inflammatory mode of cell death regulated by RIP (or RIPK)1 and RIP3 kinases and mediated by the effector MLKL. We report that diverse bacterial pathogens that produce a pore-forming toxin (PFT) induce necroptosis of macrophages and this can be blocked for protection agai...

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Detalles Bibliográficos
Autores principales:	González-Juarbe, Norberto, Gilley, Ryan Paul, Hinojosa, Cecilia Anahí, Bradley, Kelley Margaret, Kamei, Akinobu, Gao, Geli, Dube, Peter Herman, Bergman, Molly Ann, Orihuela, Carlos Javier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676650/ https://www.ncbi.nlm.nih.gov/pubmed/26659062 http://dx.doi.org/10.1371/journal.ppat.1005337

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