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Inhibition of Astrocytic Glutamine Synthetase by Lead is Associated with a Slowed Clearance of Hydrogen Peroxide by the Glutathione System

Lead intoxication in humans is characterized by cognitive impairments, particularly in the domain of memory, where evidence indicates that glutamatergic neurotransmission may be impacted. Animal and cell culture studies have shown that lead decreases the expression and activity of glutamine syntheta...

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Detalles Bibliográficos
Autores principales: Robinson, Stephen R., Lee, Alan, Bishop, Glenda M., Czerwinska, Hania, Dringen, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677102/
https://www.ncbi.nlm.nih.gov/pubmed/26696846
http://dx.doi.org/10.3389/fnint.2015.00061