The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance

The transcription factor, nuclear factor erythroid 2 p45-related factor 2 (Nrf2), acts as a sensor of oxidative or electrophilic stresses and plays a pivotal role in redox homeostasis. Oxidative or electrophilic agents cause a conformational change in the Nrf2 inhibitory protein Keap1 inducing the n...

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Autores principales: Furfaro, A. L., Traverso, N., Domenicotti, C., Piras, S., Moretta, L., Marinari, U. M., Pronzato, M. A., Nitti, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677237/
https://www.ncbi.nlm.nih.gov/pubmed/26697129
http://dx.doi.org/10.1155/2016/1958174
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author Furfaro, A. L.
Traverso, N.
Domenicotti, C.
Piras, S.
Moretta, L.
Marinari, U. M.
Pronzato, M. A.
Nitti, M.
author_facet Furfaro, A. L.
Traverso, N.
Domenicotti, C.
Piras, S.
Moretta, L.
Marinari, U. M.
Pronzato, M. A.
Nitti, M.
author_sort Furfaro, A. L.
collection PubMed
description The transcription factor, nuclear factor erythroid 2 p45-related factor 2 (Nrf2), acts as a sensor of oxidative or electrophilic stresses and plays a pivotal role in redox homeostasis. Oxidative or electrophilic agents cause a conformational change in the Nrf2 inhibitory protein Keap1 inducing the nuclear translocation of the transcription factor which, through its binding to the antioxidant/electrophilic response element (ARE/EpRE), regulates the expression of antioxidant and detoxifying genes such as heme oxygenase 1 (HO-1). Nrf2 and HO-1 are frequently upregulated in different types of tumours and correlate with tumour progression, aggressiveness, resistance to therapy, and poor prognosis. This review focuses on the Nrf2/HO-1 stress response mechanism as a promising target for anticancer treatment which is able to overcome resistance to therapies.
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spelling pubmed-46772372015-12-22 The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance Furfaro, A. L. Traverso, N. Domenicotti, C. Piras, S. Moretta, L. Marinari, U. M. Pronzato, M. A. Nitti, M. Oxid Med Cell Longev Review Article The transcription factor, nuclear factor erythroid 2 p45-related factor 2 (Nrf2), acts as a sensor of oxidative or electrophilic stresses and plays a pivotal role in redox homeostasis. Oxidative or electrophilic agents cause a conformational change in the Nrf2 inhibitory protein Keap1 inducing the nuclear translocation of the transcription factor which, through its binding to the antioxidant/electrophilic response element (ARE/EpRE), regulates the expression of antioxidant and detoxifying genes such as heme oxygenase 1 (HO-1). Nrf2 and HO-1 are frequently upregulated in different types of tumours and correlate with tumour progression, aggressiveness, resistance to therapy, and poor prognosis. This review focuses on the Nrf2/HO-1 stress response mechanism as a promising target for anticancer treatment which is able to overcome resistance to therapies. Hindawi Publishing Corporation 2016 2015-11-30 /pmc/articles/PMC4677237/ /pubmed/26697129 http://dx.doi.org/10.1155/2016/1958174 Text en Copyright © 2016 A. L. Furfaro et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Furfaro, A. L.
Traverso, N.
Domenicotti, C.
Piras, S.
Moretta, L.
Marinari, U. M.
Pronzato, M. A.
Nitti, M.
The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance
title The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance
title_full The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance
title_fullStr The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance
title_full_unstemmed The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance
title_short The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance
title_sort nrf2/ho-1 axis in cancer cell growth and chemoresistance
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677237/
https://www.ncbi.nlm.nih.gov/pubmed/26697129
http://dx.doi.org/10.1155/2016/1958174
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