A novel single-chain antibody redirects adenovirus to IL13Rα2-expressing brain tumors

The generation of a targeting agent that strictly binds to IL13Rα2 will significantly expand the therapeutic potential for the treatment of IL13Rα2-expressing cancers. In order to fulfill this goal, we generated a single-chain antibody (scFv47) from our parental IL13Rα2 monoclonal antibody and teste...

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Detalles Bibliográficos
Autores principales: Kim, Julius W., Young, Jacob S., Solomaha, Elena, Kanojia, Deepak, Lesniak, Maciej S., Balyasnikova, Irina V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677343/
https://www.ncbi.nlm.nih.gov/pubmed/26656559
http://dx.doi.org/10.1038/srep18133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677343/
https://www.ncbi.nlm.nih.gov/pubmed/26656559
http://dx.doi.org/10.1038/srep18133

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