Cargando…

A novel single-chain antibody redirects adenovirus to IL13Rα2-expressing brain tumors

The generation of a targeting agent that strictly binds to IL13Rα2 will significantly expand the therapeutic potential for the treatment of IL13Rα2-expressing cancers. In order to fulfill this goal, we generated a single-chain antibody (scFv47) from our parental IL13Rα2 monoclonal antibody and teste...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Julius W., Young, Jacob S., Solomaha, Elena, Kanojia, Deepak, Lesniak, Maciej S., Balyasnikova, Irina V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677343/ https://www.ncbi.nlm.nih.gov/pubmed/26656559 http://dx.doi.org/10.1038/srep18133

Ejemplares similares

Charachterization and functional analysis of scFv-based CARs to redirect T cells to IL13Rα2-positive glioma
por: Krenciute, Giedre, et al.
Publicado: (2015)

Hitting the nail on the head: combining oncolytic adenovirus-mediated virotherapy and immunomodulation for the treatment of glioma
por: Panek, Wojciech K., et al.
Publicado: (2017)

Mesenchymal Stem Cells Modified with a Single-Chain Antibody against EGFRvIII Successfully Inhibit the Growth of Human Xenograft Malignant Glioma
por: Balyasnikova, Irina V., et al.
Publicado: (2010)

A Comparative Study of Replication-Incompetent and -Competent Adenoviral Therapy-Mediated Immune Response in a Murine Glioma Model
por: Kim, Julius W., et al.
Publicado: (2017)

Redirecting adenovirus to pulmonary endothelium by cationic liposomes
por: Ma, Z, et al.
Publicado: (2002)

Protein Tyrosine Phosphatase-1B Inhibition Disrupts IL13Rα2-Promoted Invasion and Metastasis in Cancer Cells
por: Bartolomé, Rubén A., et al.
Publicado: (2020)

Combination of tucatinib and neural stem cells secreting anti-HER2 antibody prolongs survival of mice with metastatic brain cancer
por: Cordero, Alex, et al.
Publicado: (2021)

The Network of Cytokines in Brain Metastases
por: Fares, Jawad, et al.
Publicado: (2021)

Mesenchymal stem cell carriers enhance antitumor efficacy of oncolytic adenoviruses in an immunocompetent mouse model
por: Rincón, Esther, et al.
Publicado: (2017)

Tralokinumab Effectively Disrupts the IL-13/IL-13Rα1/IL-4Rα Signaling Complex but Not the IL-13/IL-13Rα2 Complex
por: Tollenaere, Maxim A.X., et al.
Publicado: (2023)

Intranasal Oncolytic Virotherapy with CXCR4-Enhanced Stem Cells Extends Survival in Mouse Model of Glioma
por: Dey, Mahua, et al.
Publicado: (2016)

The use of anti-GITR antibody treatment in a murine model of glioblastoma multiforme
por: Miska, Jason, et al.
Publicado: (2015)

Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters
por: Kim, Julius Woongki, et al.
Publicado: (2016)

Hypoxic-Preconditioned Bone Marrow Stem Cell Medium Significantly Improves Outcome After Retinal Ischemia in Rats
por: Roth, Steven, et al.
Publicado: (2016)

“Redirecting an anti-IL-1β antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A”
por: Fischman, Sharon, et al.
Publicado: (2023)

Enhancing the antitumor potency of T cells redirected by bispecific antibodies
por: Chang, Chien-Hsing, et al.
Publicado: (2017)

Inhibition of Liver Metastasis in Colorectal Cancer by Targeting IL-13/IL13Rα2 Binding Site with Specific Monoclonal Antibodies
por: Jaén, Marta, et al.
Publicado: (2021)

The Challenge for Gene Therapy: Innate Immune Response to Adenoviruses
por: Thaci, Bart, et al.
Publicado: (2011)

Metabolome-Driven Regulation of Adenovirus-Induced Cell Death
por: Laevskaya, Anastasia, et al.
Publicado: (2021)

Low-level whole-brain radiation enhances theranostic potential of single-domain antibody fragments for human epidermal growth factor receptor type 2 (HER2)-positive brain metastases
por: Procissi, Daniele, et al.
Publicado: (2022)

Redirecting Pore Assembly of Staphylococcal α-Hemolysin by Protein Engineering
por: Koo, Sunwoo, et al.
Publicado: (2019)

IL-13Rα2 Glycosylation Holds the Dance Card for Partnering with IL-13
por: Dy, Alane B. C., et al.
Publicado: (2020)

Influence of the bispecific antibody IgG subclass on T cell redirection
por: Kapelski, Stephanie, et al.
Publicado: (2019)

Bispecific antibodies redirect synthetic agonistic receptor modified T cells against melanoma
por: Märkl, Florian, et al.
Publicado: (2023)

Dual blockade of IL‐4 and IL‐13 with dupilumab, an IL‐4Rα antibody, is required to broadly inhibit type 2 inflammation
por: Le Floc’h, Audrey, et al.
Publicado: (2020)

Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Rα, IL-13Rα1, and γc regulates relative cytokine sensitivity
por: Junttila, Ilkka S., et al.
Publicado: (2008)

IL4Rα and IL13Rα1 Are Involved in the Development of Human Gallbladder Cancer
por: Ahn, Sung Woo, et al.
Publicado: (2022)

Targeting and pharmacology of an anti-IL13Rα2 antibody and antibody-drug conjugate in a melanoma xenograft model
por: Gupta, Parul, et al.
Publicado: (2021)

Improving adoptive T cell therapy with adenoviruse armed with TNF-α and IL-2
por: Havunen, Riikka, et al.
Publicado: (2015)

A Strategy for Adenovirus Vector Targeting with a Secreted Single Chain Antibody
por: Glasgow, Joel N., et al.
Publicado: (2009)

T-cell redirecting bispecific antibodies targeting BCMA for the treatment of multiple myeloma
por: Verkleij, Christie P.M., et al.
Publicado: (2020)

Immunotherapy of Acute Lymphoblastic Leukemia and Lymphoma With T Cell–Redirected Bispecific Antibodies
por: Lussana, Federico, et al.
Publicado: (2021)

T-cell redirecting bispecific and trispecific antibodies in multiple myeloma beyond BCMA
por: van de Donk, Niels W.C.J., et al.
Publicado: (2023)

Enhanced Transduction and Replication of RGD-Fiber Modified Adenovirus in Primary T Cells
por: Sengupta, Sadhak, et al.
Publicado: (2011)

Scratching Counteracts IL-13 Signaling by Upregulating the Decoy Receptor IL-13Rα2 in Keratinocytes
por: Ulzii, Dugarmaa, et al.
Publicado: (2019)

Design considerations of an IL13Rα2 antibody–drug conjugate for diffuse intrinsic pontine glioma
por: Lian, Xiaolei, et al.
Publicado: (2021)

IL13Rα2 signaling in colorectal cancer
por: Bartolomé, Rubén A., et al.
Publicado: (2015)

The IL-13/IL-4Rα axis is involved in tuberculosis-associated pathology
por: Heitmann, Lisa, et al.
Publicado: (2014)

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons
por: Traube, Franziska R., et al.
Publicado: (2021)

Efficacy of a new oncolytic adenovirus armed with IL-13 against oral carcinoma models
por: Zhang, Kai-Liang, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_81opg23dug35tq5q34dunmav3l