Identification of covalent active site inhibitors of dengue virus protease

Dengue virus (DENV) protease is an attractive target for drug development; however, no compounds have reached clinical development to date. In this study, we utilized a potent West Nile virus protease inhibitor of the pyrazole ester derivative class as a chemical starting point for DENV protease dru...

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Detalles Bibliográficos
Autores principales: Koh-Stenta, Xiaoying, Joy, Joma, Wang, Si Fang, Kwek, Perlyn Zekui, Wee, John Liang Kuan, Wan, Kah Fei, Gayen, Shovanlal, Chen, Angela Shuyi, Kang, CongBao, Lee, May Ann, Poulsen, Anders, Vasudevan, Subhash G, Hill, Jeffrey, Nacro, Kassoum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677662/
https://www.ncbi.nlm.nih.gov/pubmed/26677315
http://dx.doi.org/10.2147/DDDT.S94207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677662/
https://www.ncbi.nlm.nih.gov/pubmed/26677315
http://dx.doi.org/10.2147/DDDT.S94207

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