R-loops regulate promoter-proximal chromatin architecture and cellular differentiation

Numerous chromatin-remodeling factors are regulated by interactions with RNA, although the contexts and functions of RNA binding are poorly understood. Here we show that R-loops, RNA:DNA hybrids consisting of nascent transcripts hybridized to template DNA, modulate the binding of two key chromatin r...

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Detalles Bibliográficos
Autores principales: Chen, Poshen B., Chen, Hsiuyi V., Acharya, Diwash, Rando, Oliver J., Fazzio, Thomas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677832/
https://www.ncbi.nlm.nih.gov/pubmed/26551076
http://dx.doi.org/10.1038/nsmb.3122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677832/
https://www.ncbi.nlm.nih.gov/pubmed/26551076
http://dx.doi.org/10.1038/nsmb.3122

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