The α-arrestin ARRDC3 mediates ALIX ubiquitination and G protein–coupled receptor lysosomal sorting

The sorting of G protein–coupled receptors (GPCRs) to lysosomes is critical for proper signaling and cellular responses. We previously showed that the adaptor protein ALIX regulates lysosomal degradation of protease-activated receptor-1 (PAR1), a GPCR for thrombin, independent of ubiquitin-binding E...

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Detalles Bibliográficos
Autores principales: Dores, Michael R., Lin, Huilan, J. Grimsey, Neil, Mendez, Francisco, Trejo, JoAnn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678022/
https://www.ncbi.nlm.nih.gov/pubmed/26490116
http://dx.doi.org/10.1091/mbc.E15-05-0284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678022/
https://www.ncbi.nlm.nih.gov/pubmed/26490116
http://dx.doi.org/10.1091/mbc.E15-05-0284

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