Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I

The human cytomegalovirus (HCMV) US2 and US11 gene products hijack mammalian ER-associated degradation (ERAD) to induce rapid degradation of major histocompatibility class I (MHC-I) molecules. The rate-limiting step in this pathway is thought to be the polyubiquitination of MHC-I by distinct host ER...

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Detalles Bibliográficos
Autores principales: van den Boomen, D.J.H., Lehner, P.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678111/
https://www.ncbi.nlm.nih.gov/pubmed/26210183
http://dx.doi.org/10.1016/j.molimm.2015.07.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678111/
https://www.ncbi.nlm.nih.gov/pubmed/26210183
http://dx.doi.org/10.1016/j.molimm.2015.07.005

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