ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival

Genetic co-depletion of the actin-severing proteins ADF and CFL1 triggers catastrophic loss of adult homeostasis in multiple tissues. There is impaired cell-cell adhesion in skin keratinocytes with dysregulation of E-cadherin, hyperproliferation of differentiated cells, and ultimately apoptosis. Mec...

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Detalles Bibliográficos
Autores principales: Kanellos, Georgios, Zhou, Jing, Patel, Hitesh, Ridgway, Rachel A., Huels, David, Gurniak, Christine B., Sandilands, Emma, Carragher, Neil O., Sansom, Owen J., Witke, Walter, Brunton, Valerie G., Frame, Margaret C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678118/
https://www.ncbi.nlm.nih.gov/pubmed/26655907
http://dx.doi.org/10.1016/j.celrep.2015.10.056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678118/
https://www.ncbi.nlm.nih.gov/pubmed/26655907
http://dx.doi.org/10.1016/j.celrep.2015.10.056

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