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Distinct promoter activation mechanisms modulate noise-driven HIV gene expression

Latent human immunodeficiency virus (HIV) infections occur when the virus occupies a transcriptionally silent but reversible state, presenting a major obstacle to cure. There is experimental evidence that random fluctuations in gene expression, when coupled to the strong positive feedback encoded by...

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Detalles Bibliográficos
Autores principales: Chavali, Arvind K., Wong, Victor C., Miller-Jensen, Kathryn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678399/
https://www.ncbi.nlm.nih.gov/pubmed/26666681
http://dx.doi.org/10.1038/srep17661