Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts

[Image: see text] A disodium phosphonooxymethyl prodrug of the antitumor agent triptolide was prepared from the natural product in three steps (39% yield) and displayed excellent aqueous solubility at pH 7.4 (61 mg/mL) compared to the natural product (17 μg/mL). The estimated shelf life (t(90)) for...

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Detalles Bibliográficos
Autores principales: Patil, Satish, Lis, Lev G., Schumacher, Robert J., Norris, Beverly J., Morgan, Monique L., Cuellar, Rebecca A. D., Blazar, Bruce R., Suryanarayanan, Raj, Gurvich, Vadim J., Georg, Gunda I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678411/
https://www.ncbi.nlm.nih.gov/pubmed/26596892
http://dx.doi.org/10.1021/acs.jmedchem.5b01329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678411/
https://www.ncbi.nlm.nih.gov/pubmed/26596892
http://dx.doi.org/10.1021/acs.jmedchem.5b01329

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