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Direct Catalytic Enantio- and Diastereoselective Ketone Aldol Reactions of Isocyanoacetates**
A catalytic asymmetric aldol addition/cyclization reaction of unactivated ketones with isocyanoacetate pronucleophiles has been developed. A quinine-derived aminophosphine precatalyst and silver oxide were found to be an effective binary catalyst system and promoted the reaction to afford chiral oxa...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
WILEY-VCH Verlag
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678506/ https://www.ncbi.nlm.nih.gov/pubmed/25735645 http://dx.doi.org/10.1002/anie.201411852 |