Direct Catalytic Enantio- and Diastereoselective Ketone Aldol Reactions of Isocyanoacetates**

A catalytic asymmetric aldol addition/cyclization reaction of unactivated ketones with isocyanoacetate pronucleophiles has been developed. A quinine-derived aminophosphine precatalyst and silver oxide were found to be an effective binary catalyst system and promoted the reaction to afford chiral oxa...

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Detalles Bibliográficos
Autores principales: delaCampa, Raquel, Ortín, Irene, Dixon, Darren J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678506/
https://www.ncbi.nlm.nih.gov/pubmed/25735645
http://dx.doi.org/10.1002/anie.201411852
Descripción
Sumario:A catalytic asymmetric aldol addition/cyclization reaction of unactivated ketones with isocyanoacetate pronucleophiles has been developed. A quinine-derived aminophosphine precatalyst and silver oxide were found to be an effective binary catalyst system and promoted the reaction to afford chiral oxazolines possessing a fully substituted stereocenter with good diastereoselectivities and excellent enantioselectivities.

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