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Quantitative proteomics signature profiling based on network contextualization

BACKGROUND: We present a network-based method, namely quantitative proteomic signature profiling (qPSP) that improves the biological content of proteomic data by converting protein expressions into hit-rates in protein complexes. RESULTS: We demonstrate, using two clinical proteomics datasets, that...

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Detalles Bibliográficos
Autores principales: Goh, Wilson Wen Bin, Guo, Tiannan, Aebersold, Ruedi, Wong, Limsoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678536/
https://www.ncbi.nlm.nih.gov/pubmed/26666224
http://dx.doi.org/10.1186/s13062-015-0098-x