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A simple method for identifying parameter correlations in partially observed linear dynamic models

BACKGROUND: Parameter estimation represents one of the most significant challenges in systems biology. This is because biological models commonly contain a large number of parameters among which there may be functional interrelationships, thus leading to the problem of non-identifiability. Although...

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Detalles Bibliográficos
Autores principales: Li, Pu, Vu, Quoc Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678707/
https://www.ncbi.nlm.nih.gov/pubmed/26666642
http://dx.doi.org/10.1186/s12918-015-0234-3