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Assembly and dynamics of the U4/U6 di-snRNP by single-molecule FRET

In large ribonucleoprotein machines, such as ribosomes and spliceosomes, RNA functions as an assembly scaffold as well as a critical catalytic component. Protein binding to the RNA scaffold can induce structural changes, which in turn modulate subsequent binding of other components. The spliceosomal...

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Detalles Bibliográficos
Autores principales: Hardin, John W., Warnasooriya, Chandani, Kondo, Yasushi, Nagai, Kiyoshi, Rueda, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678811/
https://www.ncbi.nlm.nih.gov/pubmed/26503251
http://dx.doi.org/10.1093/nar/gkv1011