Elevation of Kynurenine Metabolites in Rat Liver and Serum: A Potential Additional Mechanism of the Alcohol Aversive and Anti-cancer Effects of Disulfiram?

AIMS: The tryptophan metabolites 3-hydroxykynurenine (3-HK) and 3-hydroxyanthranilic acid (3-HAA) inhibit the liver mitochondrial low K(m) aldehyde dehydrogenase and possess alcohol-aversive and immunosuppressant properties. As the disulfiram (DS) metabolite carbon disulphide activates enzymes formi...

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Detalles Bibliográficos
Autores principales: Badawy, Abdulla A.-B., Bano, Samina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Cellular and Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678950/
https://www.ncbi.nlm.nih.gov/pubmed/26224731
http://dx.doi.org/10.1093/alcalc/agv085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678950/
https://www.ncbi.nlm.nih.gov/pubmed/26224731
http://dx.doi.org/10.1093/alcalc/agv085

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