Cargando…

Reverse Electron Transfer Completes the Catalytic Cycle in a 2,3,5-Trifluorotyrosine-Substituted Ribonucleotide Reductase

[Image: see text] Escherichia coli class Ia ribonucleotide reductase is composed of two subunits (α and β), which form an α2β2 complex that catalyzes the conversion of nucleoside 5′-diphosphates to deoxynucleotides (dNDPs). β2 contains the essential tyrosyl radical (Y(122)(•)) that generates a thiyl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ravichandran, Kanchana R., Minnihan, Ellen C., Wei, Yifeng, Nocera, Daniel G., Stubbe, JoAnne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678968/ https://www.ncbi.nlm.nih.gov/pubmed/26492582 http://dx.doi.org/10.1021/jacs.5b09189

Ejemplares similares

A >200 meV Uphill Thermodynamic Landscape for Radical Transport in Escherichia coli Ribonucleotide Reductase Determined Using Fluorotyrosine-Substituted Enzymes
por: Ravichandran, Kanchana R., et al.
Publicado: (2016)

Structural Examination of the Transient 3-Aminotyrosyl Radical on the PCET Pathway of E. coli Ribonucleotide Reductase by Multifrequency EPR Spectroscopy
por: Seyedsayamdost, Mohammad R., et al.
Publicado: (2009)

Kinetics of Hydrogen Atom Abstraction from Substrate by an Active Site Thiyl Radical in Ribonucleotide Reductase
por: Olshansky, Lisa, et al.
Publicado: (2014)

Ribonucleotide reductase, a novel drug target for gonorrhea
por: Narasimhan, Jana, et al.
Publicado: (2022)

A Ferredoxin Disulfide Reductase Delivers Electrons to the Methanosarcina barkeri Class III Ribonucleotide Reductase
por: Wei, Yifeng, et al.
Publicado: (2015)

Convergent allostery in ribonucleotide reductase
por: Thomas, William C., et al.
Publicado: (2019)

Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an Example
por: Oyala, Paul H., et al.
Publicado: (2016)

A Chemically Competent Thiosulfuranyl Radical on the Escherichia coli Class III Ribonucleotide Reductase
por: Wei, Yifeng, et al.
Publicado: (2014)

Importance of the Maintenance Pathway in the Regulation of the Activity of Escherichia coli Ribonucleotide Reductase†
por: Hristova, Daniela, et al.
Publicado: (2008)

Bacillus subtilis Class Ib Ribonucleotide Reductase: High Activity and Dynamic Subunit Interactions
por: Parker, Mackenzie J., et al.
Publicado: (2014)

Direct interfacial Y(731) oxidation in α(2) by a photoβ(2) subunit of E. coli class Ia ribonucleotide reductase
por: Song, David Y., et al.
Publicado: (2015)

Detection of Water Molecules on the Radical Transfer Pathway of Ribonucleotide Reductase by (17)O Electron–Nuclear Double Resonance Spectroscopy
por: Hecker, Fabian, et al.
Publicado: (2021)

Kinetic model for reversible radical transfer in ribonucleotide reductase
por: Reinhardt, Clorice R., et al.
Publicado: (2022)

Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer
por: Ando, Nozomi, et al.
Publicado: (2015)

Unnatural amino acids: better than the real things?
por: Minnihan, Ellen C, et al.
Publicado: (2009)

The periodic table of ribonucleotide reductases
por: Ruskoski, Terry B., et al.
Publicado: (2021)

3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound
por: Brignole, Edward J, et al.
Publicado: (2018)

The catalytic cycle for ribonucleotide incorporation by human DNA Pol λ
por: Gosavi, Rajendrakumar A., et al.
Publicado: (2012)

Hydrogen Bond Network between Amino Acid Radical Intermediates on the Proton-Coupled Electron Transfer Pathway of E. coli α2 Ribonucleotide Reductase
por: Nick, Thomas U., et al.
Publicado: (2014)

The tyrosyl free radical in ribonucleotide reductase.
por: Gräslund, A, et al.
Publicado: (1985)

Manipulating the Bacterial Cell Cycle and Cell Size by Titrating the Expression of Ribonucleotide Reductase
por: Zhu, Manlu, et al.
Publicado: (2017)

Functional link between mitochondria and Rnr3, the minor catalytic subunit of yeast ribonucleotide reductase
por: Corcoles-Saez, Isaac, et al.
Publicado: (2019)

Radical transfer in E. coli ribonucleotide reductase: a NH(2)Y(731)/R(411)A-α mutant unmasks a new conformation of the pathway residue 731
por: Kasanmascheff, Müge, et al.
Publicado: (2016)

Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima: Structural Insights into Complex Formation
por: Morar, Mariya, et al.
Publicado: (2008)

Rational polynomial representation of ribonucleotide reductase activity
por: Radivoyevitch, Tomas, et al.
Publicado: (2005)

Ribonucleotide reductases: essential enzymes for bacterial life
por: Torrents, Eduard
Publicado: (2014)

Structure of the Nucleotide Radical Formed during Reaction of CDP/TTP with the E441Q-α2β2 of E. coli Ribonucleotide Reductase
por: Zipse, Hendrik, et al.
Publicado: (2008)

Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase
por: Liew, Li Phing, et al.
Publicado: (2016)

Structural determinants and distribution of phosphate specificity in ribonucleotide reductases
por: Schell, Eugen, et al.
Publicado: (2021)

Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present
por: Huff, Sarah E., et al.
Publicado: (2022)

(19)F Electron-Nuclear Double Resonance Reveals Interaction between Redox-Active Tyrosines across the α/β Interface of E. coli Ribonucleotide Reductase
por: Meyer, Andreas, et al.
Publicado: (2022)

Regulation of ribonucleotide reductase M2 expression by the upstream AUGs
por: Dong, Zizheng, et al.
Publicado: (2005)

A docking model of human ribonucleotide reductase with flavin and phenosafranine
por: Priya, Panneerselvam Lakshmi, et al.
Publicado: (2009)

Biofilm Modifies Expression of Ribonucleotide Reductase Genes in Escherichia coli
por: Cendra, Maria del Mar, et al.
Publicado: (2012)

Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice
por: Ylikallio, Emil, et al.
Publicado: (2010)

Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy
por: Wijerathna, Sanath R., et al.
Publicado: (2011)

The Efficacy of the Ribonucleotide Reductase Inhibitor Didox in Preclinical Models of AML
por: Cook, Guerry J., et al.
Publicado: (2014)

Structure-guided design of anti-cancer ribonucleotide reductase inhibitors
por: Misko, Tessianna A., et al.
Publicado: (2019)

Acetylation regulates ribonucleotide reductase activity and cancer cell growth
por: Chen, Guo, et al.
Publicado: (2019)

Iron Chelator Transmetalative Approach to Inhibit Human Ribonucleotide Reductase
por: Gaur, Kavita, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jk281fcud8163u5gvq26qkcss3