HuR-targeted nanotherapy in combination with AMD3100 suppresses CXCR4 expression, cell growth, migration, and invasion in lung cancer

The CXCR4 chemokine receptor plays an important role in cancer cell metastasis. The CXCR4 antagonist, AMD3100, has limited efficacy in controlling metastasis. HuR, an RNA-binding protein, regulates CXCR4 in cancer cells. We therefore investigated whether targeting HuR using a siRNA-based nanoparticl...

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Detalles Bibliográficos
Autores principales: Muralidharan, Ranganayaki, Panneerselvam, Janani, Chen, Allshine, Zhao, Yan Daniel, Munshi, Anupama, Ramesh, Rajagopal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679684/
https://www.ncbi.nlm.nih.gov/pubmed/26494555
http://dx.doi.org/10.1038/cgt.2015.55

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679684/
https://www.ncbi.nlm.nih.gov/pubmed/26494555
http://dx.doi.org/10.1038/cgt.2015.55

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