Cargando…

HuR-targeted nanotherapy in combination with AMD3100 suppresses CXCR4 expression, cell growth, migration, and invasion in lung cancer

The CXCR4 chemokine receptor plays an important role in cancer cell metastasis. The CXCR4 antagonist, AMD3100, has limited efficacy in controlling metastasis. HuR, an RNA-binding protein, regulates CXCR4 in cancer cells. We therefore investigated whether targeting HuR using a siRNA-based nanoparticl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Muralidharan, Ranganayaki, Panneerselvam, Janani, Chen, Allshine, Zhao, Yan Daniel, Munshi, Anupama, Ramesh, Rajagopal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679684/ https://www.ncbi.nlm.nih.gov/pubmed/26494555 http://dx.doi.org/10.1038/cgt.2015.55

Ejemplares similares

Folate receptor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and migration
por: Muralidharan, Ranganayaki, et al.
Publicado: (2016)

Molecular Targeting of HuR Oncoprotein Suppresses MITF and Induces Apoptosis in Melanoma Cells
por: Ahmed, Rebaz, et al.
Publicado: (2021)

HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells
por: Muralidharan, Ranganayaki, et al.
Publicado: (2017)

AMD3100/CXCR4 Inhibitor
por: De Clercq, Erik
Publicado: (2015)

HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative breast cancer cells to radiotherapy
por: Mehta, Meghna, et al.
Publicado: (2016)

IL-24 Inhibits Lung Cancer Growth by Suppressing GLI1 and Inducing DNA Damage
por: Panneerselvam, Janani, et al.
Publicado: (2019)

HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A
por: Andrade, Daniel, et al.
Publicado: (2019)

Phosphorylation of interleukin (IL)-24 is required for mediating its anti-cancer activity
por: Panneerselvam, Janani, et al.
Publicado: (2015)

Chemodrug delivery using integrin-targeted PLGA-Chitosan nanoparticle for lung cancer therapy
por: Babu, Anish, et al.
Publicado: (2017)

IL-24 modulates the high mobility group (HMG) A1/miR222 /AKT signaling in lung cancer cells
por: Panneerselvam, Janani, et al.
Publicado: (2016)

CXCR4 Antagonist AMD3100 Accelerates Impaired Wound Healing in Diabetic Mice
por: Nishimura, Yukihide, et al.
Publicado: (2011)

Molecular targets and signaling pathways regulated by interleukin (IL)-24 in mediating its antitumor activities
por: Panneerselvam, Janani, et al.
Publicado: (2013)

Polymeric Nanoparticle-Mediated Gene Delivery for Lung Cancer Treatment
por: Amreddy, Narsireddy, et al.
Publicado: (2017)

Nanosomes carrying doxorubicin exhibit potent anticancer activity against human lung cancer cells
por: Srivastava, Akhil, et al.
Publicado: (2016)

Targeting CXCL12/CXCR4 Signaling with AMD3100 Might Selectively Suppress CXCR4+ T-Cell Chemotaxis Leading to the Alleviation of Chronic Prostatitis
por: Zhang, Meng, et al.
Publicado: (2022)

CXCR4 Antagonist AMD3100 Modulates Claudin Expression and Intestinal Barrier Function in Experimental Colitis
por: Xia, Xian-Ming, et al.
Publicado: (2011)

The CXCR4 Antagonist AMD3100 Has Dual Effects on Survival and Proliferation of Myeloma Cells In Vitro
por: Kim, Ha-Yon, et al.
Publicado: (2010)

Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation
por: Yang, Feng, et al.
Publicado: (2019)

Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence
por: Yi, Jie, et al.
Publicado: (2010)

Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist
por: Broxmeyer, Hal E., et al.
Publicado: (2005)

CXCR4 Antagonist AMD3100 Reverses the Resistance to Tamoxifen in Breast Cancer via Inhibiting AKT Phosphorylation
por: Zhou, Jun, et al.
Publicado: (2020)

Inhibition of CXCR4 in Spinal Cord and DRG with AMD3100 Attenuates Colon-Bladder Cross-Organ Sensitization
por: Zhang, Hengshuai, et al.
Publicado: (2022)

Correction: Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation
por: Yang, Feng, et al.
Publicado: (2023)

Selective Enhancement of Donor Hematopoietic Cell Engraftment by the CXCR4 Antagonist AMD3100 in a Mouse Transplantation Model
por: Kang, Yubin, et al.
Publicado: (2010)

MicroRNA-146a and AMD3100, two ways to control CXCR4 expression in acute myeloid leukemias
por: Spinello, I, et al.
Publicado: (2011)

Synthesis and Evaluation of [(67)Ga]-AMD3100: A Novel Imaging Agent for Targeting the Chemokine Receptor CXCR4
por: Aghanejad, Ayuob, et al.
Publicado: (2014)

CXCR4 inhibition with AMD3100 attenuates amphetamine induced locomotor activity in adolescent Long Evans male rats
por: Mason, Briana, et al.
Publicado: (2021)

AMD3100 inhibits the migration and differentiation of neural stem cells after spinal cord injury
por: Liu, Jia-Ming, et al.
Publicado: (2017)

Hematopoietic stem cell mobilization with the reversible CXCR4 receptor inhibitor plerixafor (AMD3100)—Polish compassionate use experience
por: Basak, Grzegorz Wladyslaw, et al.
Publicado: (2010)

V3-Independent Competitive Resistance of a Dual-X4 HIV-1 to the CXCR4 Inhibitor AMD3100
por: Maeda, Yosuke, et al.
Publicado: (2014)

MOBILIZATION STUDIES IN COMPLEMENT-DEFICIENT MICE REVEAL THAT OPTIMAL AMD3100 MOBILIZATION OF HEMATOPOIETIC STEM CELLS DEPENDS ON COMPLEMENT CASCADE ACTIVATION BY AMD3100-STIMULATED GRANULOCYTES
por: Lee, HakMo, et al.
Publicado: (2009)

MCD Diet Modulates HuR and Oxidative Stress-Related HuR Targets in Rats
por: Ferrigno, Andrea, et al.
Publicado: (2023)

AMD3100 sensitizes acute lymphoblastic leukemia cells to chemotherapy in vivo
por: Yu, M, et al.
Publicado: (2011)

CXCR4 antagonist AMD3100 elicits analgesic effect and restores the GlyRα3 expression against neuropathic pain
por: Liu, Xiaoming, et al.
Publicado: (2017)

The CXCR4 Antagonist, AMD3100, Reverses Mesenchymal Stem Cell-Mediated Drug Resistance in Relapsed/Refractory Acute Lymphoblastic Leukemia
por: Wang, Shan, et al.
Publicado: (2020)

Comparison of the Response to the CXCR4 Antagonist AMD3100 during the Development of Retinal Organoids Derived from ES Cells and Zebrafish Retina
por: Wu, Yihui, et al.
Publicado: (2022)

Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs
por: Yoon, Je-Hyun, et al.
Publicado: (2014)

The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro
por: Kaur, Kawaljit, et al.
Publicado: (2017)

AMD3100 is a potent antagonist at CXCR4(R334X), a hyperfunctional mutant chemokine receptor and cause of WHIM syndrome
por: McDermott, David H, et al.
Publicado: (2011)

The CXCR4 antagonist plerixafor (AMD3100) promotes proliferation of Ewing sarcoma cell lines in vitro and activates receptor tyrosine kinase signaling
por: Berning, Philipp, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_cvhltlhu0up42most8m4ssemmr