Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2(loxP/loxP) Villin-Cre mice

OBJECTIVE: Lynch syndrome is caused by germline mutations in DNA mismatch repair genes leading to microsatellite instability (MSI) and colorectal cancer. Mesalazine, commonly used for the treatment of UC, reduces MSI in vitro. Here, we tested natural compounds for such activity and applied mesalazin...

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Detalles Bibliográficos
Autores principales: Kortüm, Benedikt, Campregher, Christoph, Lang, Michaela, Khare, Vineeta, Pinter, Matthias, Evstatiev, Rayko, Schmid, Gerald, Mittlböck, Martina, Scharl, Theresa, Kucherlapati, Melanie H, Edelmann, Winfried, Gasche, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
GI cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680183/
https://www.ncbi.nlm.nih.gov/pubmed/25429050
http://dx.doi.org/10.1136/gutjnl-2014-307663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680183/
https://www.ncbi.nlm.nih.gov/pubmed/25429050
http://dx.doi.org/10.1136/gutjnl-2014-307663

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