The RZZ complex requires the N-terminus of KNL1 to mediate optimal Mad1 kinetochore localization in human cells

The spindle assembly checkpoint is a surveillance mechanism that blocks anaphase onset until all chromosomes are properly attached to microtubules of the mitotic spindle. Checkpoint activity requires kinetochore localization of Mad1/Mad2 to inhibit activation of the anaphase promoting complex/cyclos...

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Detalles Bibliográficos
Autores principales: Caldas, Gina V., Lynch, Tina R., Anderson, Ryan, Afreen, Sana, Varma, Dileep, DeLuca, Jennifer G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680571/
https://www.ncbi.nlm.nih.gov/pubmed/26581576
http://dx.doi.org/10.1098/rsob.150160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680571/
https://www.ncbi.nlm.nih.gov/pubmed/26581576
http://dx.doi.org/10.1098/rsob.150160

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