TALENs-mediated gene disruption of FLT3 in leukemia cells: Using genome-editing approach for exploring the molecular basis of gene abnormality

Novel analytic tools are needed to elucidate the molecular basis of leukemia-relevant gene mutations in the post-genome era. We generated isogenic leukemia cell clones in which the FLT3 gene was disrupted in a single allele using TALENs. Isogenic clones with mono-allelic disrupted FLT3 were compared...

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Detalles Bibliográficos
Autores principales: Wang, Jue, Li, Tongjuan, Zhou, Mi, Hu, Zheng, Zhou, Xiaoxi, Zhou, Shiqiu, Wang, Na, Huang, Liang, Zhao, Lei, Cao, Yang, Xiao, Min, Ma, Ding, Zhou, Pengfei, Shang, Zhen, Zhou, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680874/
https://www.ncbi.nlm.nih.gov/pubmed/26669855
http://dx.doi.org/10.1038/srep18454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680874/
https://www.ncbi.nlm.nih.gov/pubmed/26669855
http://dx.doi.org/10.1038/srep18454

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