Hepatitis C virus NS5A protein blocks epidermal growth factor receptor degradation via a proline motif- dependent interaction

Hepatitis C virus (HCV) establishes a persistent infection that in many cases leads to cirrhosis and hepatocellular carcinoma. The non-structural 5A protein (NS5A) has been implicated in this process as it contains a C-terminal polyproline motif (termed P2) that binds to Src homology 3 (SH3) domains...

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Detalles Bibliográficos
Autores principales: Igloi, Zsofia, Kazlauskas, Arunas, Saksela, Kalle, Macdonald, Andrew, Mankouri, Jamel, Harris, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for General Microbiology 2015
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681064/
https://www.ncbi.nlm.nih.gov/pubmed/25872741
http://dx.doi.org/10.1099/vir.0.000145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681064/
https://www.ncbi.nlm.nih.gov/pubmed/25872741
http://dx.doi.org/10.1099/vir.0.000145

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