Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model

BACKGROUND: During the erythrocytic stage in humans, malaria parasites digest haemoglobin of the host cell, and the toxic haem moiety crystallizes into haemozoin. Chloroquine acts by forming toxic complexes with haem molecules and interfering with their crystallization. In chloroquine-resistant stra...

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Detalles Bibliográficos
Autores principales: Dambuza, Ntokozo S., Smith, Peter, Evans, Alicia, Norman, Jennifer, Taylor, Dale, Andayi, Andrew, Egan, Timothy, Chibale, Kelly, Wiesner, Lubbe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681141/
https://www.ncbi.nlm.nih.gov/pubmed/26671222
http://dx.doi.org/10.1186/s12936-015-1032-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681141/
https://www.ncbi.nlm.nih.gov/pubmed/26671222
http://dx.doi.org/10.1186/s12936-015-1032-5

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